Web4Men - Men's LifeStyle Magazine
 -  04/17/2021
Bookmark this site
Home page  Science and Technics  
If you've had the flu this year, you can look forward to only a brief respite. Chances are you'll get it again next year, and the year after that, and the year after that. Thanks to its rapid evolution, the influenza virus continually slips away from the immune system and stays ahead of researchers' efforts to stymie it. But this week, researchers report that they've nabbed antibodies that disable multiple varieties of the virus. The results might help scientists devise a universal flu vaccine or treatments that quash numerous flu strains, including the dreaded avian flu.
The key to this advance lies in a viral protein known as hemagglutinin. The protein covers the viral surface and allows it to attach to a receptor on the surface of its target cell. Hemagglutinin then performs some molecular gymnastics. These contortions enable the virus's membrane to merge with the cell's membrane, opening the way for viral entry.

Vaccines mainly provoke antibodies that target the hemagglutinin's head. But that part of the protein changes rapidly, undermining these immune defenses. Immunochemist Wayne Marasco of Harvard Medical School in Boston and colleagues discovered an unchanging part of hemagglutinin that might provide a better target when they were looking for antibodies that neutralize the avian flu. The researchers trawled their gigantic library of more than 27 billion human antibodies to determine which molecules latch onto H5, the version of hemagglutinin carried by the avian flu virus. They identified 10 antibodies that recognized different versions of H5. In solution, the antibodies could block not only H5 but also eight other types of flu virus, including the one responsible for the deadly 1918–19 flu pandemic.

Next, the team tested three of the antibodies in mice that had been infected with lethal doses of avian flu. When they received antibodies before or up to 3 days after infection, most of the rodents survived, suggesting the antibodies are therapeutic and preventive.

Structural biologist Robert Liddington of the Burnham Institute for Medical Research in San Diego, California, and his team then used x-ray crystallography to snap a close-up of one antibody affixed to hemagglutinin. Instead of glomming onto hemagglutinin's variable head, the antibody nestles into three pockets on the tail, or stem, of the virus. When the researchers checked a database with genome sequences of more than 6000 flu virus variants, they found that the amino acid sequence of this region remains constant in many viral strains. That means that an antibody that recognizes this region alone could protect against a variety of flu strains, possibly including the one that causes avian flu, the researchers conclude.

Marasco's team is moving on to animal safety tests and hopes to begin clinical trials by the 2010–11 flu season. "I think it's a very good paper," says molecular biologist Brendon Hanson of the DSO National Laboratories in Singapore, because it suggests an "available option" for stalling pandemic flu.

Nick: JirkaPraha, 4.3.2009 09:10:21
Diskuse pod příspěvkem - Přidat komentář

Jméno / nick:

Příspěvek zatím nebyl komentován, můžeš být první.

iRobot company featured idea, how resolve funding of health insurance in future. He means that robotic nurses are the best resolve. New robotic nurses could have to save millions in state budget...
Science and Technics
29.3.2010 09:19:03 | Nick: JirkaPraha
Swiss adventurer Bertrand Piccard wants fly over Atlantic ocean and than even World with solar plane called Solar Impulse. Look, how will appear fly of Solar Impulce. More about this project on...
Science and Technics
28.1.2010 09:45:44 | Nick: JirkaPraha
Anchorage (USA) – Melting of arctic glaciers that is commonly seen as an adverse effect of the global warming has at least one positive effect. Due to the melting, scientists can execute their...
Science and Technics
27.1.2010 10:00:21 | Nick: JirkaPraha
American company called Envion started service of the first recycling machine in Semptember 2009 without interest of media. This machine recycles plastic garbage made from oil and it makes oil again...
Science and Technics
30.12.2009 09:15:03 | Nick: JirkaPraha
Obesity (fatness, liposis) is situation, that natural energy backup of mammal (for example human), which is saved in fat stuff, has increased over standard value and it is dangerous for health....
Science and Technics
28.12.2009 09:49:09 | Nick: JirkaPraha
Reading of ideas went off be variety attraction and using of their power to functioning on neighborhood by effect from paranormal domain. It goes about only about practice using of magnetic...
Science and Technics
23.11.2009 09:15:52 | Nick: JirkaPraha
Rocket, which has to send American astronauts in to the space after end flies of space shuttle, has to take off on Thursday 27.10.2009 without persons. Meteorological news implies start will be on...
Science and Technics
30.10.2009 09:06:06 | Nick: JirkaPraha
Submitter of advert in countryside is interested in, what group addresses this way. System Next Generation Digital Signage Solution for recognizing of faces researched by company NEC could help them....
Science and Technics
29.10.2009 09:31:33 | Nick: JirkaPraha

Pokračujte ve výběru - články

A girl of the day
Interesting movies






Exclusive accommodation,

Prague centre. Our recommendation.



For advertisment at our site feel free to send email to
web4men ( at ) gmail.com

Czech Currency Rates
EUR Vlajka meny EUR  
GBP Vlajka meny GBP  
USD Vlajka meny USD  
CAD Vlajka meny CAD  
CHF Vlajka meny CHF  
JPY Vlajka meny JPY  
PLN Vlajka meny PLN  
RUB Vlajka meny RUB  
PX50 Vlajka meny PX50  
Interesting Info


and events in Prague


Prague,Czech Republic



Metal beauty